Fg12 ribonuclease secretion contributes to Fusarium graminearum virulence and induces plant cell death.
Identifieur interne : 000167 ( Main/Exploration ); précédent : 000166; suivant : 000168Fg12 ribonuclease secretion contributes to Fusarium graminearum virulence and induces plant cell death.
Auteurs : Bo Yang [République populaire de Chine] ; Yuyin Wang [République populaire de Chine] ; Mengjun Tian [République populaire de Chine] ; Kaixin Dai [République populaire de Chine] ; Wenyue Zheng [République populaire de Chine] ; Zehan Liu [République populaire de Chine] ; Sen Yang [République populaire de Chine] ; Xinyu Liu [République populaire de Chine] ; Dongya Shi [République populaire de Chine] ; Haifeng Zhang [République populaire de Chine] ; Yan Wang [République populaire de Chine] ; Wenwu Ye [République populaire de Chine] ; Yuanchao Wang [République populaire de Chine]Source :
- Journal of integrative plant biology [ 1744-7909 ] ; 2020.
Abstract
Filamentous fungal pathogens secrete effectors that modulate host immunity and facilitate infection. Fusarium graminearum is an important plant pathogen responsible for various devastating diseases. However, little is known about the function of effector proteins secreted by F. graminearum. Herein, we identified several effector candidates in the F. graminearum secretome. Among them, the secreted ribonuclease Fg12 was highly upregulated during the early stages of F. graminearum infection in soybean; its deletion compromised the virulence of F. graminearum. Transient expression of Fg12 in Nicotiana benthamiana induced cell death in a light-dependent manner. Fg12 possessed ribonuclease (RNase) activity, degrading total RNA. The enzymatic activity of Fg12 was required for its cell death-promoting effects. Importantly, the ability of Fg12 to induce cell death was independent of BAK1/SOBIR1, and treatment of soybean with recombinant Fg12 protein induced resistance to various pathogens, including F. graminearum and Phytophthora sojae. Overall, our results provide evidence that RNase effectors not only contribute to pathogen virulence but also induce plant cell death.
DOI: 10.1111/jipb.12997
PubMed: 32725938
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Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yuyin" sort="Wang, Yuyin" uniqKey="Wang Y" first="Yuyin" last="Wang">Yuyin Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Tian, Mengjun" sort="Tian, Mengjun" uniqKey="Tian M" first="Mengjun" last="Tian">Mengjun Tian</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Dai, Kaixin" sort="Dai, Kaixin" uniqKey="Dai K" first="Kaixin" last="Dai">Kaixin Dai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Wenyue" sort="Zheng, Wenyue" uniqKey="Zheng W" first="Wenyue" last="Zheng">Wenyue Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Zehan" sort="Liu, Zehan" uniqKey="Liu Z" first="Zehan" last="Liu">Zehan Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Sen" sort="Yang, Sen" uniqKey="Yang S" first="Sen" last="Yang">Sen Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Xinyu" sort="Liu, Xinyu" uniqKey="Liu X" first="Xinyu" last="Liu">Xinyu Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Dongya" sort="Shi, Dongya" uniqKey="Shi D" first="Dongya" last="Shi">Dongya Shi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Haifeng" sort="Zhang, Haifeng" uniqKey="Zhang H" first="Haifeng" last="Zhang">Haifeng Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yuanchao" sort="Wang, Yuanchao" uniqKey="Wang Y" first="Yuanchao" last="Wang">Yuanchao Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of integrative plant biology</title><idno type="eISSN">1744-7909</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Filamentous fungal pathogens secrete effectors that modulate host immunity and facilitate infection. Fusarium graminearum is an important plant pathogen responsible for various devastating diseases. However, little is known about the function of effector proteins secreted by F. graminearum. Herein, we identified several effector candidates in the F. graminearum secretome. Among them, the secreted ribonuclease Fg12 was highly upregulated during the early stages of F. graminearum infection in soybean; its deletion compromised the virulence of F. graminearum. Transient expression of Fg12 in Nicotiana benthamiana induced cell death in a light-dependent manner. Fg12 possessed ribonuclease (RNase) activity, degrading total RNA. The enzymatic activity of Fg12 was required for its cell death-promoting effects. Importantly, the ability of Fg12 to induce cell death was independent of BAK1/SOBIR1, and treatment of soybean with recombinant Fg12 protein induced resistance to various pathogens, including F. graminearum and Phytophthora sojae. Overall, our results provide evidence that RNase effectors not only contribute to pathogen virulence but also induce plant cell death.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32725938</PMID><DateRevised><Year>2020</Year><Month>08</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1744-7909</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jul</Month><Day>29</Day></PubDate></JournalIssue><Title>Journal of integrative plant biology</Title><ISOAbbreviation>J Integr Plant Biol</ISOAbbreviation></Journal><ArticleTitle>Fg12 ribonuclease secretion contributes to Fusarium graminearum virulence and induces plant cell death.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/jipb.12997</ELocationID><Abstract><AbstractText>Filamentous fungal pathogens secrete effectors that modulate host immunity and facilitate infection. Fusarium graminearum is an important plant pathogen responsible for various devastating diseases. However, little is known about the function of effector proteins secreted by F. graminearum. Herein, we identified several effector candidates in the F. graminearum secretome. Among them, the secreted ribonuclease Fg12 was highly upregulated during the early stages of F. graminearum infection in soybean; its deletion compromised the virulence of F. graminearum. Transient expression of Fg12 in Nicotiana benthamiana induced cell death in a light-dependent manner. Fg12 possessed ribonuclease (RNase) activity, degrading total RNA. The enzymatic activity of Fg12 was required for its cell death-promoting effects. Importantly, the ability of Fg12 to induce cell death was independent of BAK1/SOBIR1, and treatment of soybean with recombinant Fg12 protein induced resistance to various pathogens, including F. graminearum and Phytophthora sojae. Overall, our results provide evidence that RNase effectors not only contribute to pathogen virulence but also induce plant cell death.</AbstractText><CopyrightInformation>© 2020 Institute of Botany, Chinese Academy of Sciences.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Bo</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yuyin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tian</LastName><ForeName>Mengjun</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dai</LastName><ForeName>Kaixin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Wenyue</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Zehan</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Sen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Xinyu</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Dongya</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Haifeng</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ye</LastName><ForeName>Wenwu</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yuanchao</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>31721004</GrantID><Agency>National Natural Science Foundation of China</Agency><Country></Country></Grant><Grant><GrantID>BX20180142</GrantID><Agency>National Postdoctoral Program for Innovative Talents</Agency><Country></Country></Grant><Grant><GrantID>2018M640496</GrantID><Agency>China Postdoctoral Science Foundation</Agency><Country></Country></Grant><Grant><GrantID>BK20190520</GrantID><Agency>Natural Science Foundation of Jiangsu Province</Agency><Country></Country></Grant><Grant><GrantID>KYXK202010</GrantID><Agency>Fundamental Research Funds for the Central Universities</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>China (Republic : 1949- )</Country><MedlineTA>J Integr Plant Biol</MedlineTA><NlmUniqueID>101250502</NlmUniqueID><ISSNLinking>1672-9072</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Fusarium graminearum</Keyword><Keyword MajorTopicYN="N">cell death</Keyword><Keyword MajorTopicYN="N">effector</Keyword><Keyword MajorTopicYN="N">fungal ribonuclease</Keyword><Keyword MajorTopicYN="N">virulence</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32725938</ArticleId><ArticleId 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Nat Plants 2: 1-6</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name></noRegion><name sortKey="Dai, Kaixin" sort="Dai, Kaixin" uniqKey="Dai K" first="Kaixin" last="Dai">Kaixin Dai</name><name sortKey="Dai, Kaixin" sort="Dai, Kaixin" uniqKey="Dai K" first="Kaixin" last="Dai">Kaixin Dai</name><name sortKey="Liu, Xinyu" sort="Liu, Xinyu" uniqKey="Liu X" first="Xinyu" last="Liu">Xinyu Liu</name><name sortKey="Liu, Xinyu" sort="Liu, Xinyu" uniqKey="Liu X" first="Xinyu" last="Liu">Xinyu Liu</name><name sortKey="Liu, Zehan" sort="Liu, Zehan" uniqKey="Liu Z" first="Zehan" last="Liu">Zehan Liu</name><name sortKey="Liu, Zehan" sort="Liu, Zehan" uniqKey="Liu Z" first="Zehan" last="Liu">Zehan Liu</name><name sortKey="Shi, Dongya" sort="Shi, Dongya" uniqKey="Shi D" first="Dongya" last="Shi">Dongya Shi</name><name sortKey="Shi, Dongya" sort="Shi, Dongya" uniqKey="Shi D" first="Dongya" last="Shi">Dongya Shi</name><name sortKey="Tian, Mengjun" sort="Tian, Mengjun" uniqKey="Tian M" first="Mengjun" last="Tian">Mengjun Tian</name><name sortKey="Tian, Mengjun" sort="Tian, Mengjun" uniqKey="Tian M" first="Mengjun" last="Tian">Mengjun Tian</name><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name><name sortKey="Wang, Yuanchao" sort="Wang, Yuanchao" uniqKey="Wang Y" first="Yuanchao" last="Wang">Yuanchao Wang</name><name sortKey="Wang, Yuanchao" sort="Wang, Yuanchao" uniqKey="Wang Y" first="Yuanchao" last="Wang">Yuanchao Wang</name><name sortKey="Wang, Yuyin" sort="Wang, Yuyin" uniqKey="Wang Y" first="Yuyin" last="Wang">Yuyin Wang</name><name sortKey="Wang, Yuyin" sort="Wang, Yuyin" uniqKey="Wang Y" first="Yuyin" last="Wang">Yuyin Wang</name><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name><name sortKey="Yang, Sen" sort="Yang, Sen" uniqKey="Yang S" first="Sen" last="Yang">Sen Yang</name><name sortKey="Yang, Sen" sort="Yang, Sen" uniqKey="Yang S" first="Sen" last="Yang">Sen Yang</name><name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name><name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name><name sortKey="Zhang, Haifeng" sort="Zhang, Haifeng" uniqKey="Zhang H" first="Haifeng" last="Zhang">Haifeng Zhang</name><name sortKey="Zhang, Haifeng" sort="Zhang, Haifeng" uniqKey="Zhang H" first="Haifeng" last="Zhang">Haifeng Zhang</name><name sortKey="Zheng, Wenyue" sort="Zheng, Wenyue" uniqKey="Zheng W" first="Wenyue" last="Zheng">Wenyue Zheng</name><name sortKey="Zheng, Wenyue" sort="Zheng, Wenyue" uniqKey="Zheng W" first="Wenyue" last="Zheng">Wenyue Zheng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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